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apalutamide will minimize the extent or outcome of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with drugs that are CYP2C19 substrates may end up in decrease exposure to those prescription drugs.Hyponatremia: Clinically considerable hyponatr